Clinical Studies with China-made Teniposide in the Treatment of Advanced Human Cancers

Objective To evaluate the clinical usefulness of China-made teniposide in the treatment of several advanced human cancers.methods A total of 152 Patients were enrolled in a multicenter cooperative study.Of them,24 patients were given iv teniposide 60mg/m2 for consecutive five days among 21 days and 128 patients were given combination chemotherapy containing either China-made teniposide or Vamon. Results Teniposide is effective in patients with small cell lung cancer (SCLC) and malignant lymphoma(ML),with response rate(RR) of 43.8% and 42.8%,respectively.The major side effects were leukopenia,gastrointestinal reaction and alopecia.In the controlled study of combination chemotherapy with teniposide and vamon,the total RR of combination chemotherapy either containing teniposide or Vamon in SCLC and HL were 77.4% and 68.3%,respectively(P>0.05).The RR of combination chemotherapy containing teniposide in brain tumors was 46.2%,with 52.6% in primary brain tumor. Conclusion The efficacy and side effect of both drugs were comparable.