Experiment study on enhancement of antitumor effect of mitomycin Cbyverapamil in human Cervical Cancer

Objective To determine the reversion of mitomycin(MMC)resistance by verapamil (VER)in vitro and in vivo. Methods A xenografted mitomycin resistant mice model of cervical cancer was devoleped.The reversion of mitomycin of resistance by VER was detected for human cervical cancar cell(hela)and its resistant subline Hela/MMC in vitro and in vivo. Results nontoxin doses of VER might enhance the cytotoxicity of MMC in Hela and Hela/MMC,could result in almost complete or partial reversion of MMC resisistance of Hei...