Abstract:
Objective To analyze the prognostic value of SUVmax, ΔSUVmax, MTV and BCL-2 and BCL-6 expression on DLBCL patients.
Methods We retrospectively analyzed the 18F-FDG PET/CT manifestation of 55 DLBLC patients, and evaluated the middle-stage chemotherapy effect with 5-PS by 18F-FDG PET/CT scan. Chi-square test was used for analysing the correlation of the chemotherapy efficacy with SUVmax, ΔSUVmax, MTV and the expression of BCL-2 and BCL-6. Kaplan-Meier analysis and Cox regression analysis were used for the predictive value of ΔSUVmax, MTV, Deauville score and the expression of BCL-2 and BCL-6 on the 2-years PFS of DLBCL patients.
Results There was no correlation between SUVmax and the middle-stage chemotherapy effect (P > 0.05); ΔSUVmax, MTV and the expression of BCL-2 and BCL-6 were positively correlated with chemotherapy effect (P=0.029, 0.005, 0.001, 0.014). By univariate and multivariate analyses, there were statistical differences in 2-years PFS between ΔSUVmax < 10.6, MTV < 30.1 cm3, Deauville score < 4, BCL-6(-) groups and ΔSUVmax≥10.6, MTV≥30.1 cm3, Deauville score≥4, BCL-6(+) groups (P < 0.05). There was statistical difference in 2-years PFS of the patients with BCL-2 by univariate analysis (P=0.039).
Conclusion There are negatively correlation between ΔSUVmax, MTV and the middle-stage chemotherapy effect. Patients with BCL2(-) and BCL-6(-) have good efficacy. ΔSUVmax, MTV, Deauville score and BCL-6 are independent prognostic factors for the 2-years PFS of DLBCL patients.
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