Abstract:
Objective To evaluate the relation between the expression of programmed cell death protein receptor-1 (PD-L1) and 18F-deoxyglucose (18F-FDG) uptake in lung adenocarcinoma.
Methods We retrospectively analyzed the clinical data of 102 patients with pathologically-confirmed lung adenocarcinoma who underwent 18F-FDG PET/CT examinations before treatment and immunohistochemical examination after treatment to detect the expression of PD-L1. The relation between the maximum standard uptake of 18F-FDG(SUVmax) and the expression of PD-L1 was analyzed.
Results PD-L1 positive were detected in 50 patients (49%), the SUVmax was significantly higher in PD-L1 positive patients than that in the negative patients (6.59±5.03 vs. 2.89±4.65, P=0.0001). For the prediction of PD-L1 expression by SUVmax, the area under the ROC curve was 0.801, P=0.0001; when the cut off value was 1.70, the maximum value of Jordan index was 0.522.
Conclusion 18F-FDG uptake is associated with PD-L1 expression in primary lung adenocarcinoma, and the patients with high SUVmax are more likely to harbor PD-L1 expression.
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