Objective To summarize the clinical manifestation, pathological features of primary gastrointestinal non-Hodgkin's lymphoma (PGINHL) and investigate their prognostic factors.

Methods The clinical data of 272 patients diagnosed as PGINHL was analyzed retrospectively.

Results Man versus female was 1.32:1(155:117) with an average diagnosed age of 55.96 years, the median diagnosed age was 58.85 years (range 4.85-92.87 years). The most commen lesions was stomach (180 cases, 66.2%), followed by small bowel (31 cases, 11.4%), ileocecum (19 cases, 7%), colon (19 cases, 7%), rectum (4 cases, 1.5%), caecum and anus (each 1 cases, 0.4%), while multiple involvement were 17 cases (6.25%). 259 cases (95.2%) were classified as B cell lymphoma, while T/NK cell lymphoma were 13 cases (4.8%). 3 years and 5 years over survival rates of patients were 87.5% and 82.2%, respectively. Simple surgical gained the worst survival status, while there were no obvious differences between chemotherapy combined surgical or radiotherapy and surgical combined chemotherapy. Univariate analysis revealed that age > 60 years, T cell phenotype, advanced phase patients, high age adjusted IPI risk score, high actate dehydrogenase (LDH) level and β2-MG level, Ki67 > 40% and the tumor diameter≥10 cm were predictors for poor prognosis, Cox hazard modeling was used to analysis that T cell type, higher aaIPI risk score, beta 2 microspheres (β2-MG) level and Ki67 were independent predictors for overall survival of patients with PGINHL.

Conclusion pathological type, LDH, β2-MG and Ki67 were not preferential survival factors for PGINHL. PGINHL patients can choose chemotherapy or chemotherapy combined with radiotherapy as the first -line treatment regimen.