Abstract: Lipid metabolism is one of the most important metabolic pathways in the organism, and it playscentral roles in the homeostasis. Fatty acid and lipid droplets are two processes in lipid metabolism. More andmore researches confirmed that it had certain relationship between lipid metabolism and the proliferation of cancers. Recent studies have demonstrated that the microenvironment of cancer cells is affected by the unsaturatedlipids metabolism. Lipid droplets proteins are involved in the occurrence and development of malignanttumors. In this review, we will summarize the relationship between lipid metabolism and cancer development,and the potential mechanism under them, and explore the significance of lipid metabolism and cancer.