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结直肠癌组织中Krüppel样因子17的表达及其与预后的关系

孟庆彬, 吴彪, 肖新波, 邵永胜, 闵凯, 瞿紫微, 冯燕, 王静, 易继林

孟庆彬, 吴彪, 肖新波, 邵永胜, 闵凯, 瞿紫微, 冯燕, 王静, 易继林. 结直肠癌组织中Krüppel样因子17的表达及其与预后的关系[J]. 肿瘤防治研究, 2015, 42(03): 256-260. DOI: 10.3971/j.issn.1000-8578.2015.03.010
引用本文: 孟庆彬, 吴彪, 肖新波, 邵永胜, 闵凯, 瞿紫微, 冯燕, 王静, 易继林. 结直肠癌组织中Krüppel样因子17的表达及其与预后的关系[J]. 肿瘤防治研究, 2015, 42(03): 256-260. DOI: 10.3971/j.issn.1000-8578.2015.03.010
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MENG Qingbin, WU Biao, XIAO Xinbo, SHAO Yongsheng, MIN Kai, QU Ziwei, FENG Yan, WANG Jing, YI Jilin. Expression of KLF17 Protein in Human Colorectal Cancer Tissue and Its Correlation with Prognosis[J]. Cancer Research on Prevention and Treatment, 2015, 42(03): 256-260. DOI: 10.3971/j.issn.1000-8578.2015.03.010
Citation: MENG Qingbin, WU Biao, XIAO Xinbo, SHAO Yongsheng, MIN Kai, QU Ziwei, FENG Yan, WANG Jing, YI Jilin. Expression of KLF17 Protein in Human Colorectal Cancer Tissue and Its Correlation with Prognosis[J]. Cancer Research on Prevention and Treatment, 2015, 42(03): 256-260. DOI: 10.3971/j.issn.1000-8578.2015.03.010
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结直肠癌组织中Krüppel样因子17的表达及其与预后的关系

  • 1. 430022 武汉，武汉市第一医院胃肠外科；2. 430022 武汉，武汉市第一医院病理科；3.430030 武汉，华中科技大学同济医学院附属同济医院普外科

详细信息
    作者简介:

    孟庆彬（1982-），男，博士，住院医师，主要从事胃肠肿瘤方面的研究

    通讯作者:

    吴彪，E-mail:wubiao2008@126.com

  • 中图分类号: R735.3

Expression of KLF17 Protein in Human Colorectal Cancer Tissue and Its Correlation with Prognosis

  • 1. Department of Gastrointestinal Surgery, The First Hospital of Wuhan City, Wuhan 430022,China; 2. Department of Pathology, The First Hospital of Wuhan City, Wuhan 430022, China;3. Department of General Surgery, The Affiliated Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China

摘要

    摘要
  • 摘要: 目的 研究Krüppel样因子17(Krüppel-like factor 17, KLF17)在结直肠癌组织中的表达及其与患者临床病理特征及预后的关系。方法 收集武汉市第一医院128例结直肠癌患者的临床病理资料，采用免疫组织化学法检测KLF17在结直肠癌及对应的非癌结直肠黏膜组织中的表达，Kaplan-Meier法绘制生存曲线，Cox比例风险模型进行生存分析。结果 128例结直肠癌中，83例癌组织存在KLF17低表达。KLF17低表达与结直肠癌患者淋巴结转移相关（P=0.012）。KLF17低表达患者5年无病生存率及总生存率分别为46.3%和49.3%，明显低于KLF17高表达患者的78.3%和82.0%（P均=0.001）。Cox 模型分析结果显示：KLF17、术前肠梗阻、肿瘤分化程度和病理学N分期是结直肠癌患者无病生存时间及总生存时间的独立预后因素（P均＜0.05）。结论 KLF17低表达与结直肠癌淋巴结转移相关，是结直肠癌患者预后不良的一个潜在分子指标。

     

    Abstract: Objective To investigate the expression of Krüppel-like factor 17 (KLF17) in colorectal cancer tissue and its correlation with patients' clinicopathologic features and prognosis. Methods Expression of KLF17 was examined by immunohistochemical staining of paraffin-embedded tumor specimens from 128 colorectal cancer patients who underwent curative surgery at The First Hospital of Wuhan City. Survival curves were described by Kaplan-Meier method. Univariate and multivariate analysis were performed with Cox proportional hazard model. Results Expression of KLF17 in tumor cells was significantly downregulated in 83 patients. Low expression of KLF17 was strongly correlated with pN stage (P=0.012). Kaplan-Meier analysis revealed that patients with low KLF17 expression had lower 5-year disease-free survival and 5-year overall survival rates (46.3% and 49.3%) than those with high KLF17 expression(78.3% and 82.0%) (all P=0.001). Univariate and multivariate analysis showed that KLF17 expression, preoperative obstruction, tumor differentiation and pN stage were independent factors for both disease-free survival and overall survival of colorectal cancer patients (all P＜0.05). Conclusion Low expression of KLF17 in colorectal cancer cells is correlated with pN stage and is an independent predictor for poor survival of colorectal cancer patients.

     

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出版历程
  • 收稿日期:  2014-04-29
  • 修回日期:  2014-11-25
  • 刊出日期:  2015-03-24

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