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胰腺癌肝转移患者多学科综合治疗临床分析

李泽朝, 周勇, 罗诗樵

李泽朝, 周勇, 罗诗樵. 胰腺癌肝转移患者多学科综合治疗临床分析[J]. 肿瘤防治研究, 2015, 42(02): 154-158. DOI: 10.3971/j.issn.1000-8578.2015.02.012
引用本文: 李泽朝, 周勇, 罗诗樵. 胰腺癌肝转移患者多学科综合治疗临床分析[J]. 肿瘤防治研究, 2015, 42(02): 154-158. DOI: 10.3971/j.issn.1000-8578.2015.02.012
LI Zechao, ZHOU Yong, LUO Shiqiao. Clinical Analysis of Multimodality Treatments for Pancreatic Cancer Patients with Liver Metastases[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 154-158. DOI: 10.3971/j.issn.1000-8578.2015.02.012
Citation: LI Zechao, ZHOU Yong, LUO Shiqiao. Clinical Analysis of Multimodality Treatments for Pancreatic Cancer Patients with Liver Metastases[J]. Cancer Research on Prevention and Treatment, 2015, 42(02): 154-158. DOI: 10.3971/j.issn.1000-8578.2015.02.012

胰腺癌肝转移患者多学科综合治疗临床分析

基金项目: 重庆市医学科技计划项目(2008-2-02)
详细信息
    作者简介:

    李泽朝(1987-),男,硕士,主要从事肝胆胰腺疾病的防治研究

    通讯作者:

    罗诗樵,E-mail:luoshiqiao@hotmail.com

  • 中图分类号: R735.9

Clinical Analysis of Multimodality Treatments for Pancreatic Cancer Patients with Liver Metastases

  • 摘要: 目的 对胰腺癌肝转移患者的临床特征及不同治疗模式分析,探讨不同治疗模式对患者生存预后的影响。方法 回顾性分析2009年1月至2012年1月重庆医科大学附属第一医院64例胰腺癌肝转移患者的临床资料,对其临床特征和治疗模式分别用Kaplan-Meier法及Cox模型进行单因素及多因素分析。结果 64例患者总的中位生存时间(median survival time, MST)为4月,6月、1年及2年生存率(overall survival, OS)分别为39.1%、21.9%和7.8%。单因素分析显示,年龄、疼痛、厌食、CA19-9水平、ALT和GGT水平、手术、介入化疗栓塞/介入化疗、积极治疗及多学科综合治疗是预后影响因素。多因素分析示:肝外转移、疼痛、CA19-9、积极治疗、手术、介入化疗栓塞/介入化疗及多学科综合治疗与生存预后密切相关。结论 对胰腺癌肝转移患者,疼痛、CA19-9≥1 000 u/ml及合并肝外转移提示预后不良。积极治疗、手术、介入化疗栓塞/介入化疗及多学科综合治疗可明显提高患者生活质量,延长生存时间。

     

    Abstract: Objective To analyze the clinical features of pancreatic cancer patients with liver metastasis and multimodality treatments, and to explore the impact of multimodality treatments on the prognosis of pancreatic cancer patients. Methods We retrospectively analyzed 64 pancreatic cancer patients with liver metastasis hospitalized in The First Affiliated Hospital of Chongqing Medical University from January 2009 to January 2012. Prognostic factors in clinical features and multimodality treatments were analyzed by Kaplan-Meier method and Cox regression model with SPSS19.0 software. Results The median survival time (MST) was 4 month. 6-month, 1-year and 2-year overall survival (OS) were 39.1%, 21.9% and 7.8% respectively. Univariate analysis revealed that there were significant differences in age, pain, anorexia, CA19-9, ALT and GGT levels, surgery, chemotherapy embolism/ transarterial chemotherapy, active treatment and multi-disciplinary treatment. Multivariate analysis showed that extrahepatic metastasis, pain, CA19-9, active treatment, surgery, chemotherapy embolism/transarterial chemotherapy and multi-disciplinary treatment were closely related to the survival and prognosis of patients. Conclusion In pancreatic cancer patients with liver metastases, pain, CA19-9≥1 000 u/ml and extrahepatic metastases at diagnosis are adverse prognostic factors. Active treatment, surgery, chemotherapy embolism/transarterial chemotherapy and multi-disciplinary treatment could improve the quality of life and prolong the survival time of pancreatic cancer patients with liver metastases.

     

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出版历程
  • 收稿日期:  2014-05-12
  • 修回日期:  2014-06-22
  • 刊出日期:  2015-02-24

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