Abstract: Objective 　To investigate the expression and clinical pathology associated factor of MRP and LRP. Methods 　Ninety-two paraffin embedded primary colorectal carcinoma specimens were examined by immunohistochemical staining (S2P) . Results 　Of the 92 tumor specimens examined, 38 cases (41. 30 %) and 78 cases (84. 78 %) were positively immunostained for MRP and LRP, respectively. 36 (39. 13 %) were positively immunostained for both MRP and LRP. And the two factors are related with each other. Positive immunostaining of LRP was just correlated with depth of tumor invasion. Conclusion 　These two drug resistance associated proteins were closely correlated with the multidrug resistance of colorectal carcinoma. To examine their expression may help guide rational comprehensive therapy of colorectal carcinomas.