Abstract: Objective To retrospectively analyze the clinical characteristics and long-term treatment outcome of 107 cases of extranodal NK/T-cell lymphoma of nasal type (ENKTL) and investigate the prognostic factors. Methods One hundred and seven cases of patients with pathologically confirmed ENKTL who were admitted to Fujian Provincial Tumor Hospital from January 2002 to December 2010 were analyzed. Univariate analysis was firstly applied for each clinical and laboratory characteristic. The statistically significant factors were then included in multivariate analysis. Results In 107 patients, 74 were male and 33 were female (MDK∶F=2.2∶1), with median age of 42 years (range, 9 to 83 years). The most common sites of involvement were nasal cavity (75 cases, 70%), followed by Waldeyer's ring (24 cases, 22%) and others (8 cases). Twelve cases (11%) involved in cervical lymph nodes and only 2 patients had bone marrow metastasis. According to the Ann Arbor staging system, 82% patients were staged as Ⅰ/Ⅱ, 83% had international prognostic index (IPI) of 0~1, and 52% presented with B symptoms. Twenty six patients received chemotherapy alone, 26 patients received radiotherapy alone, and the other 55 patients received radiochemotherapy. The complete response rate for all patients was 61% and the five-year survival rate was 47.2%. Multivariate Cox regression model analysis showed that age, stage and complete remission were all independent prognostic factors of NK/T cells lymphadenoma. Conclusion ENKTL is more often seen in male patients accompanied by B symptoms. Nasal cavity and Waldeyer's ring are the most common primary sites. Radiotherapy and chemotherapy are the main treatment. Age, stage and complete remission to primary treatment are independent prognostic factors.