Abstract: Objective To investigate the therapeutical effect and side-effect of vinorelbine and Shen Qi Fu Zheng Injection(SFI) combined with Radiation Therapy for elderly esophageal cancer．Methods Sixty elderly patients with esophageal squamous cell carcinoma were randomly divided into the radiotherapy group (RT group，n=30) and Vinorelbine and SFI combined with Radiation Therapy group (CRT group，n=30). Radiation dose was （50.4-54）Gy/(28-30) fraction in CRT group and （63-66.6）Gy/（35-37）fraction in RT group. Results Effective rate was 96.67% in CRT group and higher than that in RT group (80.00%，P=0.044). The median survival in CRT patients was longer than that in RT patients (23.0 months vs. 16.5 months). 3-year survival rate in CRT group was increased,compared with RT group (33.33% vs. 10.00%，P=0.028). The incidence of side effects of CRT group was similar to RT group. Conclusion CRT group had a longer survival, and acceptable toxicity,compared with RT group. For older patients, radiation therapy combined with vinorelbine and SFI was able to improve their long- term survival.