Abstract: Objective To investigate the effect of GP and NP chemotherapy on anemia to elderly NSCLC patients. Method Sixty patients were selected in the past five years, and divided into GP and NP group randomly. Hb, RBC, HCT and iron metabolism of all cases and were detected at the first, second and fourth week. Result The Hb, RBC, HCT and sFn of all the patients in two groups descended after one week. At the second week, all the indexes were the lowest, while in the fourth week each index recovered. Conclusion To elderly NSCLC patients, GP and NP chemotherapy resulted into anemia, however, which was tolerant through dose and interval regulation.