MMP-7和survivin在胃癌组织中的表达及意义

Expression and Significance of MMP-7 and survivin in Gastric Cancer

摘要: 目的探讨MMP-7和survivin在胃癌组织中的表达及意义。方法应用免疫组织化学SP法分别检测MMP-7、survivin在61例胃癌和30例正常胃黏膜中的表达情况，结合患者临床病理资料进行综合分析。结果MMP-7、survivin表达与肿瘤的浸润深度、淋巴结转移、TNM分期、分化程度、5年生存时间相关（P<0.05)，与胃癌患者年龄、性别、肿瘤大小、部位均无关(P>0.05)。结论MMP-7、survivin表达上调可能与胃癌的发生、发展有关。

Abstract: Objective To investigate the expression and significance of MMP-7 and survivin in gastric cancer.MothodsImmunohistochemical assay was used to detect the expressions of MMP-7 and survivin in 61 gastric carcinoma specimens and 30 gastric mucosa membrane.And the result with consolidation of clinical pathological materials was analyzed. Results Expressions of MMP-7 and survivin were correlated with tumor invasion,lymph node metastasis,TNM staging,tumor differentiation,and five years survival time(P<0.05),and were not positively correlated with age grading，gender，tumor sizes and position (P>0.05). Conclusion Overexpressions of MMP-7 and survivin correlate with occurrence and development of gastric cancer.