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非小细胞肺癌组织中caveolin-1和cathepsin D的表达及其与MVD的相关性

马华玲, 杨赤兵, 陈卫斌, 张文娟, 李玲, 陈洪雷, 朱润庆

马华玲, 杨赤兵, 陈卫斌, 张文娟, 李玲, 陈洪雷, 朱润庆. 非小细胞肺癌组织中caveolin-1和cathepsin D的表达及其与MVD的相关性[J]. 肿瘤防治研究, 2012, 39(11): 1333-1336. DOI: 10.3971/j.issn.1000-8578.2012.11.013
引用本文: 马华玲, 杨赤兵, 陈卫斌, 张文娟, 李玲, 陈洪雷, 朱润庆. 非小细胞肺癌组织中caveolin-1和cathepsin D的表达及其与MVD的相关性[J]. 肿瘤防治研究, 2012, 39(11): 1333-1336. DOI: 10.3971/j.issn.1000-8578.2012.11.013
Ma Hualing, Yang Chibing, Chen Weibin, Zhang Wenjuan, Li Ling, Chen Honglei, Zhu Runqing. Expressions of caveolin-1,cathepsin D and Their Correlation with MVD in Non-small Cell Lung Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(11): 1333-1336. DOI: 10.3971/j.issn.1000-8578.2012.11.013
Citation: Ma Hualing, Yang Chibing, Chen Weibin, Zhang Wenjuan, Li Ling, Chen Honglei, Zhu Runqing. Expressions of caveolin-1,cathepsin D and Their Correlation with MVD in Non-small Cell Lung Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(11): 1333-1336. DOI: 10.3971/j.issn.1000-8578.2012.11.013

非小细胞肺癌组织中caveolin-1和cathepsin D的表达及其与MVD的相关性

基金项目: 国家自然科学基金资助项目(30900652)
详细信息
    作者简介:

    马华玲(1979-),女,硕士,主治医师,主要从事肿瘤病理方面的研究

    通讯作者:

    杨赤兵,E-mail:491127451@qq.com

  • 中图分类号: R734.2

Expressions of caveolin-1,cathepsin D and Their Correlation with MVD in Non-small Cell Lung Carcinoma

  • 摘要: 目的 探讨caveolin-1和cathepsin D蛋白在非小细胞肺癌(non-small cell lung carcinoma,NSCLC)中的表达及其与微血管密度(microvessel density,MVD)及临床病理特征之间的关系。方法用免疫组织化学法检测caveolin-1和cathepsin D在86例NSCLC和20例癌旁肺组织中的表达,以及CD34在NSCLC中的表达,并对MVD计数。结果caveolin-1在NSCLC组织中表达率显著低于癌旁肺组织(P=0.000);而cathepsin D在NSCLC组织中表达率显著高于癌旁肺组织(P=0.024)。caveolin-1和cathepsin D的表达均与TNM分期(P1=0.001;P2=0.008)和淋巴结转移有关(P1=0.032;P2=0.001)。caveolin-1和cathepsin D阳性病例的MVD值明显高于阴性病例(P=0.000)。caveolin-1与cathepsin D在NSCLC中呈正相关(r=0.307;P=0.004)。结论caveolin-1在肺癌中具有双重作用;caveolin-1、cathepsin D高表达可能刺激间质内微血管密度增高,共同促进肺癌的侵袭和转移。

     

    Abstract: Objective To study the expression of caveolin-1 and cathepsin D in non-small cell lung carcinoma (NSCLC) and their correlation with microvessel density (MVD) and clinicopathologic parameters. Methods Immunohistochemistry staining was used to detect caveolin-1,cathepsin D expression in 68 NSCLCs and 20 adjacent noncancerous lung tissues and CD34 expression in NSCLC.MVD was detected by CD34 immunostaining. Results The positive rate of caveolin-1 protein in NSCLC was significantly lower than those in adjacent noncancerous lung tissues (P=0.000).On the contrary,the positive rate of cathepsin D in NSCLC was significantly higher than those in adjacent noncancerous lung tissues(P=0.024).Caveolin-1 and cathepsin D expression were both correlated with higher TNM stage (P1=0.001;P2=0.008) and lymph node metastasis (P1=0.032;P2=0.001).MVD in the positive expression of caveolin-1 and cathepsin D were higher than those in the negative cases(P=0.000).The expression caveolin-1 was positively correlated with the expression of cathepsin D in the NSCLC(r=0.307;P=0.004). Conclusion caveolin-1 may have a dual effect in the NSCLC.High expression of caveolin-1 and cathepsin D may play a vital role in the progression of NSCLC and closely correlate with tumor angiogenesis.

     

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出版历程
  • 收稿日期:  2012-01-04
  • 修回日期:  2012-04-12
  • 刊出日期:  2012-11-24

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