Abstract: Objective To assess the influencing factors,treatment and prognosis of malignant tumor patients with venous thomboembolic events(VIE). Methods The clinical data, including the site of thrombosis,platelet,D-dimer and fibrinogen level,of 33 patients with malignant tumor and VTE were retrospectively analyzed. Results One case complicated with pulmonary embolism(PTE) died within 4 h.Among the other 32 cases with deep venous thrombosis(DVT),11 cases obtained complete response,8 partial response,and 14 progress proceed.D-dimer and fibrinogen increased when VTE occurred.The median survival time of patients with high level D-dimer was 80 d which was lower than those patients with low levels(420 d).They showed significant difference(P=0.026). Conclusion The main treatments of anti-VTE are anticoagulation and anti-assembly.D-dimer,Fibrinogen in the diagnosis and prognosis determination of the patients with VTE are important prognostic factors.