Abstract: Objective To investigate the relationship between epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment effects and serum tumor markers in lung adenocarcinoma. Methods Forty-eight patients with advanced lung adenocarcinoma were treated with EGFR-TKI.The clinical features,survival time and the level of serum tumor markers for the patients before and after treatment were retrospectively analyzed. Results After EGFR-TKI treatment,the RR was 58.3% and DCR was 65.6% in lung adenocarcinoma;and median survival time was 13.2 months.Responses correlated significantly with smoking history and level of CEA or CA19-9 in serum(P<0.05).Patients with higher level of serum CEA and CA19-9 had higher disease control rate and longer survival(P<0.05). Conclusion Serum CA19-9 or CEA level can predict the response of EGFR-TKI to lung adenocarcinoma.