Abstract: Objective To investigate the expression of SHP-1 and SHP-2 protein in nasopharyngeal carcinoma and their relationship with clinical characteristics. Methods Immunohistochemistry was used to detect the SHP-1 and SHP-2 protein in 53 patients with nasopharyngeal carcinoma(NPC) and 21 normal nasopharyngeal tissues.At the same time，the relationship between SHP-1 and SHP-2 and clinicopathological factors were analyzed. Results The rate of positive expression of SHP-1 was significantly higher in nasopharyngeal carcinoma tissues than that in normal nasopharyngeal tissues(64.2% vs.28.6%，P<0.01).The expression rate of SHP-2 in NPC was 30.2%，while that in normal nasopharyngeal tissues was 33.3%.There was no statistic significance(P>0.05).The expression of SHP-1 in NPC tissues was correlated with differentiation，lymph node metastasis，T stage and clinical stage，but didn′t relate to gender and age. Conclusion SHP-1 may participate in the development and progression of nasopharyngeal carcinoma，and may be used to predict the metastasis of nasopharyngeal carcinoma.