[1] |
Calvert PM,Frucht H.The genetics of colorectal cancer[J].Ann Intern Med,2002,137(7):603-612.
|
[2] |
Troppmair J,Bruder JT,Munoz H,et al.Mitogen-activated protein kinase extracellular signal-regulated protein kinase activation by oncogenes,serum,and 12-O-tetradecanoylphorbol-13-acetaterequires Raf and is necessary for transformation[J].J Biol Chem,1994,269(9):7030-7035.
|
[3] |
Taupin D,Podolsky DK.Mitogen-activated protein kinase activation regulates intestinalepithelial differentiation[J].Gastroenterology,1999,116(5):1072-1080.
|
[4] |
Knutson JR,Lida J,Fields GB,et al.CD44/chondroitin sulfate proteoglycan and alpha 2 beta 1integrin mediate human melanoma cell migration on type Ⅳ collagen and invasion of basementmembranes[J].Mol Biol Cell,1996,7(3):383-396.
|
[5] |
Peláez IM,Kalogeropoulou M,Ferraro A,et al.Oncogenic RAS alters the global and gene-specifichistone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells[J].Int J Biochem Cell Biol,2010,42(6):911-920.
|
[6] |
Kress TR,Raabe T,Feller SM.High Erk activity suppresses expression of the cell cycleinhibitor p27Kip1 in colorectal cancer cells[J].Cell Commun Signal,2010,8(1):1.
|
[7] |
Watanabe M,Ishiwata T,Nishigai K,et al.Overexpression of keratinocyte growth factor incancer cells and enterochromaffin cells in human colorectal cancer[J].Pathol Int,2000,50(5):363-372.
|
[8] |
Chao C,Han X,Ives K,et al.CCK2 receptor expression transforms non-tumorigenic human NCM356colonic epithelial cells into tumor forming cells[J].Int J Cancer,2010,126(4):864-875.
|
[9] |
van Belzen N,Dinjens WN,Diesveld MP,et al.A novel gene which is up-regulated during colonepithelial cell differentiation and down-regulated in colorectal neoplasms[J].Lab Invest,1997,77(1):85-92.
|
[10] |
Wang Z,Wang GY,Wang F.N-myc downstream regulatecl gene 1 and tumor[J].Zhonghua Bing Li Xue ZaZhi,2003,3(2):162-164.[王震,王国英,王芳.分化相关基因NDRG1与肿瘤[J].中华病理学杂志,2003,32(2):162-164.]
|
[11] |
Agarwala KL,Kokame K,Kato H,et al.Phosphorylation of RTP,an ER stress-responsivecytoplasmic protein [J].Biochem Biophys Res Commun,2000,272(3):641-647.
|
[12] |
Taketomi Y,Sunaga K,Tanaka S,et al.Impaired mast cell maturation and degranulation andattenuated allergic responses in ndrg1-deficient mice[J].J Immunol,2007,178(11):7042-7053.
|
[13] |
Guan RJ,Ford HL,Fu Y,et al.Drg-1 as a differentiation-related,putative metastaticsuppressor gene in human colon cancer [J].Cancer Res,2000,60(3):749-755.
|
[14] |
Nishio S,Ushijima K,Tsuda N,et al.Cap43/NDRG1/Drg-1 is a molecular target for angiogenesisand a prognostic indicator in cervical adenocarcinoma[J].Cancer Lett,2008,264(1):36-43.
|
[15] |
Park H,Adams MA,Lachat P,et al.Hypoxia induces the expression of a 43-kDa protein (PROXY-1)in normal and malignant cells[J].Biochem Biophys Res Commun,2000,276(1):321-328.
|
[16] |
Lachat P,Shaw P,Gebhard S,et al.Expression of NDRG1,a differentiation-related gene,inhuman tissues[J].Histochem Cell Biol,2002,118(5):399-408.
|
[17] |
Kalaydjieva L,Gresham D,Gooding R,et al.N-myc downstream-regulated gene 1 is mutated inhereditary motor and sensory neuropathy-Lom[J].Am J Hum Genet,2000,67(1):47-58.
|
[18] |
Sonja S,Roh V,Keogh A,et al.Hypoxia increases cytoplasmic expression of NDRG1,but isinsufficient for its membrane localization in human hepatocellular carcinoma[J].FEBS Lett,2007,581(5):989-994.
|
[19] |
Ellen TP,Ke Q,Zhang P,et al.NDRG1,a growth and cancer related gene:regulation of geneexpression and function in normal and disease states[J].Carcinogenesis,2008,29 (1):2-8.
|
[20] |
Bandyopadhyay S,Pai SK,Gross SC,et al.The Drg-1 gene suppressur tumor metastasis inprostate cancer[J].Cancer Res,2003,63(8):1731-1736.
|
[21] |
Stein S,Thomas EK,Herzog B,et al.NDRG1 is necessary for p53-dependent apoptosis[J].J BiolChem,2004,279(47):48930-48940.
|
[22] |
Ahmed N,Oliva K,Wang Y,et al.Downregulation of urokinase plasminogen activator receptorexpression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells[J].Br J Cancer,2003,89(2):374-384.
|
[23] |
Folkman J.Tumor angiogensis:role in regulation of tumor growth[J].Symp Soc Dev Biol,1974,30(0):43-52.
|
[24] |
Strzelczyk B,Szulc A,Rzepko R,et al.Identification of high-Risk Stage Ⅱ colorectal tumorsby combined analysis of the NDRG1 gene expression and the depth of tumor invasion[J].Ann SurgOncol,2009,16(5):1287-1294.
|
[25] |
Crews CM,Alessandrini A,Erikson RL.The primary structure of MEK a protein kinase thatphosphorylates the ERK gene product (extracellular signal-regulated kinases) [J].Science,1992,258(5081):478-480.
|
[26] |
Alessi DR,Saito Y,Campbell DG,et al.Identification of the sites in MAP kinase kinase-1phosphorylated by p74raf-1[J].EMBO J,1994,13(7):1610-1619.
|
[27] |
Rosen LB,Ginty DD,Weber MJ,et al.Membrane depolarization and calcium influx stimulate MEKand MAP kinase via activation of Ras[J].Neuron,1994,12(6):1207-1221.
|