胸中段食管癌调强放疗近期疗效观察

Observation of Short-term Efficacy of Intensity-modulated Radiotherapy for Middle Thoracic Esophageal Carcinoma

摘要: 目的探讨胸中段食管癌调强放射治疗(IMRT)的近期疗效及不良反应。方法采用IMRT方法，治疗胸中段食管癌41例，单次分割剂量为每次2.0 Gy，1次/天，5次/周。总剂量50～68 Gy。结果治疗结束、治疗后3月总有效率(CR+PR)分别为95.1%、92.7％。仅4例3级急性放射性食管炎、2例3级白细胞减少，余不良反应均为0～2级。结论IMRT治疗胸中段食管癌患者可获得局部控制率，不良反应轻，在一定范围内安全可靠，有利于食管癌根治放疗的顺利进行。

Abstract: Objective To evaluate the short-term effect and adverse reactions of IMRT for middle thoracic esophageal carcinoma. Methods Fouty-one patients with middle thoracic esophageal carcinoma received IMRT with total prescription dose of 50~68 Gy and with 25~34 fractions.2.0 Gy/fraction，5 fractions/week. Results The overall response rate was 95.1% after radiotherapy and 92.7% 3 month respectively.The toxicities were acceptable except four patient with grade Ⅲ esophagitis and two patient with grade Ⅲ leukocytopenia. Conclusion The local control rate of middle thoracic esophageal carcinoma treated with IMRT was encouraging and this treatment was safe and reliable which might guarantee the completion of IMRT.