胸腺瘤组织中c-myc基因的表达及其意义

The Significance and Expression of c-myc in Thymomas

摘要: 目的研究c-myc基因在胸腺瘤组织中的表达,探讨c-myc基因与胸腺瘤的发生发展、恶性程度的关系。方法应用免疫组织化学SP法,检测c-myc在41例胸腺瘤和18例非肿瘤胸腺组织中的表达,结合胸腺瘤WHO分型、Masaoka分期,研究c-myc基因在胸腺瘤各分型、分期中的表达情况。结果c-myc在胸腺瘤中的阳性表达率为63.4%,在非肿瘤胸腺组织中的阳性表达率为16.7%,两者间有统计学差异(P<0.01)。c-myc在良性胸腺瘤(A/AB型)和恶性胸腺瘤(B1~B3型)中的表达分别为30.0%和74.2%,两者有统计学差异(P<0.05)。c-myc在非侵袭性胸腺瘤(Ⅰ期)与侵袭性胸腺瘤(Ⅱ~Ⅳ期)中的表达分别为33.3%和75.9%,两者有统计学差异(P<0.05)。结论c-myc与胸腺瘤的发生发展有关;与胸腺瘤的恶性程度、侵袭性有关。

Abstract: Objective To correlate the expression of c-myc in the thymomas with histological type, clinical stage. Methods c-myc's expression in paraffin-embedded sections of 41 thymomas and 18 non-neoplastic thymus were detected by immunohistochemical SP assay. Results The positive rates of c-myc in thymomas and non-neoplastic thymus was 63.4% (26/41), 16.7% (3/18). And the different was significant (P< 0.01 ). The difference of c-myc positive rate in thymomas was significant between WHO histological type A/AB ( 30...