SFRP1和Wnt-1在宫颈鳞癌中的表达及意义

王美红; 李兵; 张式暖

doi:10.3971/j.issn.1000-8578.2011.06.019

SFRP1和Wnt-1在宫颈鳞癌中的表达及意义

Expression and Significance of SFRP1 and Wnt-1 in Cervical Squamous Cell Carcinoma

摘要

摘要: 目的探讨SFRP1和Wnt-1在宫颈鳞癌中的表达及意义。方法采用免疫组织化学SP法检测SFRP1和Wnt-1蛋白在20例宫颈正常鳞状上皮、70例宫颈上皮内瘤变（cervical intraepithelial neoplasia，CIN）及50例宫颈鳞癌中的表达。结果（1）宫颈正常鳞状上皮、CINⅠ、CINⅡ/Ⅲ及宫颈鳞癌组织中，SFRP1阳性表达率分别是100%、73.5%、67.5%、34%（χ²=30.85，P<0.005)；Wnt-1的阳性表达率分别是25%、60%、82.5%、98%（χ²=45.57, P<0.005）。（2）SFRP1和Wnt-1在宫颈鳞癌中的表达无相关性（P>0.05）。（3）在宫颈鳞癌组织中，两者表达与患者的年龄、肿瘤大小、临床分期无相关性(P均>0.05)，而在不同组织分化程度间表达差异有统计学意义(P均<0.05)。结论SFRP1和Wnt-1参与了宫颈鳞状上皮的恶性转化过程，在由CIN发展到宫颈鳞癌的过程中起了促进作用。

Abstract: Abstract： ObjectiveTo explore the expression and significance of SFRP1 and Wnt-1 in cervical squamous cell carcinoma. MethodsSFRP1 and Wnt-1 were detected by immunohistochemistry(SP) in 20 cases of normal cervical squamous epithelium, 30 cases of CINⅠ,40 cases of CINⅡ/Ⅲ and 50 cases of cervical squamous cell carcinoma. Results(1)In normal cervical squamous epithelium, CINⅠ, CINⅡ/Ⅲ and cervical squamous cell carcinoma, the positive expression rate of SFRP1 were 100%, 73.5%, 67.5% and 34% respectively. The positive expression rate of Wnt-1 were 25%, 60%, 82.5% and 98% respectively. There was significantly different among four groups(P<0.05).(2)There was no correlation between SFRP1 and Wnt-1 in cervical squamous cell carcinoma.(3)In cervical squamous cell carcinoma group, there was no significant difference for SFRP1 and Wnt-1 expression in different age patient groups, and there was no difference among different tumor size, and clinical stages. However, there was significant difference among different pathological grades(P<0.05). ConclusionSFRP1 and Wnt-1 were related to the process of cancerating of cervical squamous epithelium, which maybe play important roles in the development from cervical intraepithelium neoplasis to invasive cervical squamous cell carcinoma.

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