Abstract: ObjectiveTo study the diagnostic values of co-detections of traditional serum tumor marker(Cyfra21-1) and serum proteomic patterns by surface-enhanced laser desorption and ionization time-flight mass spectrometry (SELDI-TOF-MS) technology in patients with lung squamous carcinoma. MethodsSerum samples of 59 lung squamous carcinoma patients and 60 healthy controls were detected by electrochemiluminescence to analyze the levels of Cyfra21-1,meantime SELDI-TOF-MS and CM10-chips were employed to detect the differential expressions of proteins in serum. Combined with clinical pathological materials,the diagnostic values of two methods combination were evaluated. ResultsThe sensitivity and specificity of Cyfra21-1 detection were 77.966% and 96.667%,while SELDI-TOF-MS technology were 83.051% and 65.385%.Combined detections of two methods were 94.915% and 95.000% respectively. ConclutionThe sensitivity of co-detection was higher than that of single detection.The specificity of co-detection was higher than that of SELDI-TOF-MS technology.