Abstract: ObjectiveTo investigate expression of Soluble Interleutin-2 Receptor(sIL-2R), vascular endothelial growth factor(VEGF) and CA125 in nude mice bearing human ovarian carcinoma induced by adverse psychological stress. Methods All nude mice were randomly divided into 4 groups(each n=6)： normal control group(Ⅰ),simple stress group(Ⅱ),tumor group(Ⅲ),and tumor plus stress group(Ⅳ).Adverse psychological stress model and human ovarian carcinoma xenografts model were established in correlated groups.The growth of tumors was observed in nude mice.The weight of subcutaneous tumor was measured，the concentrations of sIL-2R,VEGF and CA125 in serum were detected by enzyme-linked immunoabsorbent assay (ELISA). Results Compared with tumor group, human ovarian carcinoma xenografts growed faster in tumor plus stress group,the tumor growth rate was 66.33%（P<0.05）.The level of sIL-2R,VEGF in simple tress group was significantly higher than those in normal control group（P<0.05）.Expression of CA125 level in simple stress group was not significant difference with that innormal control group（P>0.05）.Tumor group and normal control group, tumor plus stress group and normal control group were significantly different compared with correlated group(P<0.05),the concentrations of sIL-2R,VEGF and CA125 in serum were significantly higher than that in correlated control group（P<0.05）. Conclusion Adverse psychological stress can suppress the immune function of tumor-bearing nude mice, and result in rapid growth of tumors.