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卵巢癌99mTc-MIBI显像与化疗疗效的相关性

刘楠楠, 申东兰, 陈晓秋, 何艳玲, 高 宙, 胡 疏

刘楠楠, 申东兰, 陈晓秋, 何艳玲, 高 宙, 胡 疏. 卵巢癌99mTc-MIBI显像与化疗疗效的相关性[J]. 肿瘤防治研究, 2009, 36(12): 1050-1053. DOI: 10.3971/j.issn.1000-8578.2009.12.016
引用本文: 刘楠楠, 申东兰, 陈晓秋, 何艳玲, 高 宙, 胡 疏. 卵巢癌99mTc-MIBI显像与化疗疗效的相关性[J]. 肿瘤防治研究, 2009, 36(12): 1050-1053. DOI: 10.3971/j.issn.1000-8578.2009.12.016
LIU Nan-nan, SHEN Dong-lan, CHEN Xiao-qiu, HE Yan-ling, GAO Zhou, HU Shu. Correlation Between99mTc-MIBI Scintigraphy of Ovarian Cancer and Efficacy of Chemotherapy[J]. Cancer Research on Prevention and Treatment, 2009, 36(12): 1050-1053. DOI: 10.3971/j.issn.1000-8578.2009.12.016
Citation: LIU Nan-nan, SHEN Dong-lan, CHEN Xiao-qiu, HE Yan-ling, GAO Zhou, HU Shu. Correlation Between99mTc-MIBI Scintigraphy of Ovarian Cancer and Efficacy of Chemotherapy[J]. Cancer Research on Prevention and Treatment, 2009, 36(12): 1050-1053. DOI: 10.3971/j.issn.1000-8578.2009.12.016

卵巢癌99mTc-MIBI显像与化疗疗效的相关性

详细信息
  • 中图分类号: R737.31

Correlation Between99mTc-MIBI Scintigraphy of Ovarian Cancer and Efficacy of Chemotherapy

  • 摘要: 目的 探讨卵巢癌99mTc-MIBI显像与化疗疗效的关系及临床意义。 方法 对28例卵巢癌复发患者进行99mTc-MIBI显像,采集10 min及60 min两时相的平面像,采用感兴趣区(ROI)技术计算早期和延迟相肿瘤/非肿瘤(T/N)比值及滞留指数(RI);采用TP方案进行化疗,并与T/N、滞留指数进行相关性分析。 结果 T/N比值及滞留指数低者,对化疗不敏感;T/N比值高、滞留指数高者,化疗有效,差异有统计学意义。 结论 99mTc-MIBI亲肿瘤显像能预测卵巢癌化疗敏感性,为临床个体化治疗提供理论依据。

     

    Abstract: Objective To evaluate the relationship between the 99mTc-MIBI Scintigraphy of ovarian cancer and the efficacy of chemotherapy. Methods Twenty-eight patients with advanced ovarian cancer underwent 99mTc-MIBI cintigraphy. Static planar images were taken at 10 min and 60 min after scintigraphy. Meanwhile technique of region-of-interest (ROI) was used to calculate T/ N and retention indices of 99mTc -MIBI.Each patient received chemotherapy of TP. Results The patients with low T/N and low retention indices had poor efficacy of chemotherapy. The patients with high T/N and high retention have good efficacy of chemotherapy. There was significant difference between two groups. Conclusion The 99mTc-MIBI Scintigraphy may be used to evaluate the efficacy of chemotherapy in ovarian cancer,and thus can offer theoretical basis for individual therapy.

     

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出版历程
  • 收稿日期:  2008-08-04
  • 修回日期:  2008-10-26
  • 刊出日期:  2010-01-24

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