P-gp和CD44v6在胃癌组织中表达及与预后的关系
Expressions of P-gp and CD44v6 in Gastric Carcinoma and Their Correlation to Clinical Prognosis
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摘要: 目的 探讨P-gp和CD44v6在胃癌组织中表达的相关性及其临床意义。方法 应用免疫组织化学方法,检测97例胃癌组织中P-gp及CD44v6的表达,并分析P-gp和CD44v6与胃癌病理特征的关系、两者表达的相互关系及对预后的影响。结果 97例胃癌组织中P-gp和CD44v6的阳性率分别为40.21%(39/97)和58.76%(57/97),P-gp阳性表达情况与胃癌的临床分期、有无淋巴结转移及有无血管侵犯有关(P<0.05)。CD44v6阳性表达与病变大小、临床分期、有无淋巴结转移及有无血管侵犯有关(P<0.05)。P-gp阳性表达与CD44v6阳性表达具有正相关性(P<0.05)，两者表达均阳性者3年生存率低于两者表达均阴性组。结论 P-gp和CD44v6的表达不仅与胃癌的生物学行为有关，同时两者的表达具有明显的正相关性,而且两者表达均阳性者预后差，提示联合检测两者有助于判断胃癌的预后。Abstract: Objective To study the relationship between the expression of P-glycoprotein (P-gp) and CD44v6 as well as their clinical significance in gastric carcinoma. Methods The expressions of P-gp and CD44v6 were detected by immunohistochemistry method in 97 patients with gastric carcinoma.Then their relationship with pathophysiologicalcharacteristics was evaluated.Meanwhile,the relationship between expression of P-glycoprotein (P-gp) and CD44v6 and the effect of them on clinical prognosis were also analyzed. Results The positive rate of P-gp and CD44v6 in 97 cases of gastric carcinoma were 40.21%and58.76%respectively.The expression of P-gp was associated with lymph node metastasis,vessel invasion and clinical stage; CD44v6 was associated with tumor size,lymph node metastasis,vessel invasion and clinical stage.There was a positive correlation between the expressions of P-gp and CD44v6.Moreover,survival rate of three years in both positive group was lower than that in both negative groups. Conclusion The expressions of P-gp and CD44v6 are not only associated with biologic behavior of gastric carcinoma,but also related to each other.Those who expressed both P-gp and CD44v6 have lower survival rate.Combined detecting of P-gp and CD44v6 may contribute to predicting the prognosis in gastric carcinoma.
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