Abstract: Objective To study the Ezrin and survivin expression and their correlation and clinical significances in NSCLC. Methods The expression of Ezrin and survivin were detected in 86 NSCLC by Envision method of immunohistochemical staining.Their relations with the clinical pathologic and other characters were analyzed. Results The high expression rate of Ezrin in non-small cell lung cancer was 60.5%and significantly correlated with lymph node metastasis（P<0.05）,but not associated with gender,histologic subtype, TNM stages,differentiation and smoking.Meanwhile，the high expression rate of survivin in non-small cell lung cancer was 65.1%and significantly correlated with TNM stages and lymph node metastasis（P<0.05）,while not associated with gender,histologic subtype, differentiation and smoking.The expression of Ezrin and survivin was coincident in NSCLC（r= 0.384）. Conclusion Ezrin and survivin might play synergetic roles in the process of carcinogenesis of NSCLC.Their expression may be close associated with non-small cell lung cancer metastasis, combination detection of Ezrin and survivin may be valuable for diagnosing lung cancer metastasis and providing evidence for clinical treatment.