pS2蛋白在乳腺癌中的表达及意义

Expression and significance of pS2 protein in breast cancer

摘要: 目的　研究 pS2蛋白在乳腺癌中的表达及其临床意义。方法　应用免疫组化S P法检测 10 0例原发性乳腺癌患者雌激素调节蛋白 pS2的表达。结果　 10 0例乳腺癌患者中, pS2阳性表达 5 7例, 占5 7%, 阴性表达 4 3例, 占 4 3% ;pS2阳性表达与月经状况、ER、PR相关, 与肿瘤大小、临床分期、淋巴结状况无关 ;pS2阳性表达者较阴性表达者五年生存率高, 复发率低。单因素分析显示, pS2蛋白与乳腺癌患者的预后相关, pS2阳性表达者的预后优于 pS2阴性表达者 (P =0 .0 0 0 8,风险比 0 .370 )。多因素分析显示, pS2是影响患者术后生存的重要生物学指标。结论　pS2蛋白可能是预测乳腺癌患者预后的一个独立的预后因子。

Abstract: Objective To study the expression and significance of pS2 protein in breast cancer . Methods Applying immunohistochemical technique(S-P), pS2 protein in 100cases of breast cancer was detected . Results There were 57 patients with pS2 protein positive expression, and 43 with negative expression . There was significant correlation between pS2 protein and menopausal status, ER status, PR status respectively . Neither tumor size, clinical stage, nor lymph node status was significantly related with the ex...