核因子-κB p65在宫颈癌组织中的表达及意义

Expression and Significance of Nuclear Factor-kappa B in Cervical Carcinoma

摘要: 目的　探讨NF κBp6 5蛋白在宫颈鳞癌及宫颈腺癌组织中表达的意义。方法　采用免疫组织化学方法, 用NF κBp6 5单克隆抗体检测 6 4例宫颈鳞癌组织, 6例宫颈腺癌组织, 11例宫颈上皮内瘤样病变 (CIN)组织, 16例慢性宫颈炎组织中NF κBp6 5的表达。结果　NF κBp6 5在宫颈鳞癌和腺癌中的阳性表达明显高于CIN和慢性宫颈炎组织, 有淋巴转移的癌组织中NF κBp6 5的阳性表达率高于无淋巴转移的癌组织。结论　NF κBp6 5蛋白在宫颈癌的发生发展中起重要作用

Abstract: Objective To investigate the expression of nuclear factor-kappa B(NF-κB) in human cervical squamous carcinoma tissues and cervical adenocarcinoma tissues. Methods Immunohistochemistry method detection was performed with a special anti p65 monoclonal antibody in 64 cases of cervical squamous carcinoma tissues,6 cases of adenocarcinoma tissues,11 case of cervical intracpithelial neoplasia,16 case of cervicitis. Results NF-κB p65 positive expression rate in cervical squamous carcinomas tissues and cervical a...