p53、bcl-2、nm23基因表达与胃癌生物学行为关系的研究

Relation of p53 bcl-2 and nm23-H1 protein expression to the biological characteristics of gastric cancer

摘要: 目的　研究胃组织中bcl 2、p5 3、nm2 3基因的表达与临床病理的关系, 探讨bcl 2、p5 3、nm2 3基因与胃癌生物学行为的相关性。方法　对 80例胃癌组织, 37例不典型增生癌旁组织及 2 0例正常粘膜进行免疫组化检测。结果　bcl 2蛋白在癌旁轻、中、重度不典型增生的阳性率分别为 3%、1 9.2 %、2 1 %, 各组间无显著性差异 (P >0 .0 5 ), 高分化胃癌组织阳性率为 78.2 %, 明显高于低分化胃癌组织的 4 8.0 % (P <0 .0 5 ) ;p5 3在高分化胃癌中阳性率为 5 2 %, 明显低于低分化组的87.5 % (P <0 .0 5 ) ;nm2 3在胃癌组织中阳性表达率为 6 0 %, 明显高于低分化及伴有淋巴结转移胃癌组织 (P <0 .0 5 )。p5 3与bcl 2呈明显负相关。结论　bcl 2、p5 3和nm2 3的表达不仅与胃癌细胞的分化等级密切相关, 还对患者预后有重要参考价值

Abstract: Objective To study the relationship among the expression of p53? bcl 2 and nm23 H1 and clinicopathology in the patients with gastric cancer. Methods 80 cases of different differentiated gastric cancer, 37 cases of peri tumor atypical mucosa hyperplasia and 20 cases of normal gastric mucosa were stained by immunohistochemical SP method. Results The positive rates of bcl 2 protein expression on mild, middle, severe peri tumor atypical hyperplasia were 3.1%, 19.2%, 21.0% .There was no obvious d...