非小细胞肺癌中伴神经内分泌分化及c-erbB-2表达的意义

Significance of c-erbB-2 Expression and Neuroendocrine Differentiation in Non-small CellLung Carcinoma

摘要: 目的　探讨非小细胞肺癌(NSCLC) 伴神经内分泌分化(NE) 与原癌基因c-erbB-2 表达的关系。方法　观察非小细胞肺癌32 例,用免疫组织化学S-P 法来判定神经内分泌分化及c-erbB-2 表达特点。结果　NSCLC 中24 例有NE 分化,c-erbB-2 在伴NE 分化和无NE 分化的表达阳性率比较,差异有显著性,NE 分化的阳性率和癌细胞分化程度有显著性差异。c-erbB-2 阳性在淋巴结转移组表达与无淋巴结转移组表达相比有显著性差异。结论　c-erbB-2 的过表达在非小细胞肺癌中与其侵袭性的生物学行为密切相关。c-erbB-2 过表达可用来判断NE 分化的非小细胞肺癌预后。

Abstract: Objective 　To investigate significance of c-erbB-2 expression in non-small cell lung carcinoma (NSCLC) with neuroendocrine (NE) differentiation. Methods 　32 cases of NSCLC were studied with conventional histopathological and immunohistochemical stains. Results 　There were 75 % cases of 32 NSCLC with NE. Remarkable difference was found in c-erbB-2 expression in NSCLC with NE and without NE. Conclusion 　Neuroendocrine differentiation of NSCLC is a st rongly close correlated with c-erbB-2 expression and Neuroendocrine differentiation of NSCLC can be the prognostic factor.