Abstract: Objective To investigate the expression of MUC1 in gallbladder carcinomas and its clinicopathological significance. Methods Expression of MUC1 was detected by PV6000 immunohistochemical method in gallbladder carcinomas and normal mucosa beside the carcinomas. Results All normal mucosa beside the carcinomas were negative for MUC1. In the 60 cases of gallbladder carcinomas, positive rate of MUC1 was 51.7% .The expressions of MUC1 in gallbladder carcinomas was significantly higher than that in normal mucosa beside the carcinomas (P<0.05) . No significant correlation was found between the expression of MUC1 and other clinical pathological data and prognosis. Conclusion There was a higher positive rate of MUC1 in gallbladder carcinomas, which indicated that MUC1 may play an important role in the development of the tumor.