高级搜索

探讨18F-FDG SPECT/CT在胃癌疗效评价中的价值

赖灿辉, 杨建伟, 张江灵, 陈少谊, 陈韵彬, 唐明灯

赖灿辉, 杨建伟, 张江灵, 陈少谊, 陈韵彬, 唐明灯. 探讨18F-FDG SPECT/CT在胃癌疗效评价中的价值[J]. 肿瘤防治研究, 2010, 37(06): 679-682. DOI: 10.3971/j.issn.1000-8578.2010.06.019
引用本文: 赖灿辉, 杨建伟, 张江灵, 陈少谊, 陈韵彬, 唐明灯. 探讨18F-FDG SPECT/CT在胃癌疗效评价中的价值[J]. 肿瘤防治研究, 2010, 37(06): 679-682. DOI: 10.3971/j.issn.1000-8578.2010.06.019
LAI Can-hui, YANG Jian-wei, ZHANG Jiang-ling, CHEN Shao-yi, CHEN Yun-bin, TANG Ming-deng. Study of Value of 18F-FDG SPECT/CT in Evaluation of Treatment Response in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(06): 679-682. DOI: 10.3971/j.issn.1000-8578.2010.06.019
Citation: LAI Can-hui, YANG Jian-wei, ZHANG Jiang-ling, CHEN Shao-yi, CHEN Yun-bin, TANG Ming-deng. Study of Value of 18F-FDG SPECT/CT in Evaluation of Treatment Response in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(06): 679-682. DOI: 10.3971/j.issn.1000-8578.2010.06.019

探讨18F-FDG SPECT/CT在胃癌疗效评价中的价值

详细信息
  • 中图分类号: R735.2

Study of Value of 18F-FDG SPECT/CT in Evaluation of Treatment Response in Gastric Cancer

  • 摘要: 目的 探讨18F-FDG SPECT/CT(18F-FDG coincidence single photon emission computed tomography/multi-detector computed tomography,18F-FDG SPECT/CT)所测定T/B值在胃癌临床疗效评价的价值。 方法 对31例未治疗的新发的原发性胃癌患者化疗前后进行MDCT增强扫描与 18F-FDG SPECT/CT断层显像并测定T/B值。根据患者MDCT的疗效判定结果,初步探讨18F-FDG SPECT/CT的T/B值进行疗效评价的标准。 结果 18F-FDG SPECT/CT中的T/B值下降率R△T/B与肿瘤最大径之和的下降率R△MD存在显著的直线相关(相关系数Rs=0.867, P<0.001);18F-FDG SPECT/CT中的R△T/B预测胃癌疗效的ROC曲线图的面积为0.943,其准确率为94.3%。若分别设R△T/B为35%、40%为基线,判定客观缓解OR(Objective remission,OR, CR+PR)的灵敏度分别为100%、85.7%,特异度94.1%、100%,阳性预测值93.3%、100%,阴性预测值100%、89.5%;判定有效率RR的结果分别为48.4%、38.7%。 结论 胃癌T/B值的改变率进行疗效评价具有较高的准确性,我们推荐T/B值下降35%以上作为临床判定客观缓解、无缓解的分界点。

     

    Abstract: Objective To Study the value of in 18F-FDG SPECT/CT (18F-FDG coincidence single photon-emission computed tomography/multi-detector computed tomography) in the evaluation of treatment response in gastric cancer. Methods MDCT (multi-detector computed tomography) enhancement scanning and 18F-FDG SPECT/CT was performed in 31 untreated patients with diagnosed gastric cancer. Then, chemotherapy with FOLFOX4 4Cycles was administrated on the 31 patients. 2 weeks after four Cycles of chemotherapy, both MDCT and 18F-FDG SPECT were performed in 31 patients. Criterion in MDCT was used to evaluate the treatment response. Then, the value of T/B was discussed by the treatment response. Results Kappa coefficient of the values of R△T/B [1-(T/B)after chemotherapy/(T/B)before chemotherapy] of 18F-FDG SPECT/CT and R△MD (1- MaxiDiameterafter chemotherapy/MaxiDiameter before chemotherapy) of MDCT is 0.867(P<0.01).The accuracy of R△T/B to predict the treatment response is 94.3%. If we make the base line of R△T/B as 35%, The sensitivity, specificity, positive predictive value,negative predictive value of 18F-FDG SPECT/CT were 100%, 94.1%,93.3% and 100% respectively. If R△T/B is 40%,the results are 85.7%,100%,100% and 89.5% respectively. Conclusion The changed rate of the value of T/B in 18F-FDG SPECT/CT in gastric cancer is accurate and feasible. We recommend the value of T/B decrease more than 35% as the demarcation of Objective remission and No remission.

     

计量
  • 文章访问数:  2607
  • HTML全文浏览量:  38
  • PDF下载量:  490
  • 被引次数: 0
出版历程
  • 收稿日期:  2009-01-18
  • 修回日期:  2009-09-14
  • 刊出日期:  2010-06-24

目录

    /

    返回文章
    返回
    x 关闭 永久关闭