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COX-2 选择性抑制剂Celecoxib 治疗胶质瘤的体内实验研究

杨武双, 刘金凤, 杨德林, 岳 武

杨武双, 刘金凤, 杨德林, 岳 武. COX-2 选择性抑制剂Celecoxib 治疗胶质瘤的体内实验研究[J]. 肿瘤防治研究, 2005, 32(02): 67-69. DOI: 10.3971/j.issn.1000-8578.2466
引用本文: 杨武双, 刘金凤, 杨德林, 岳 武. COX-2 选择性抑制剂Celecoxib 治疗胶质瘤的体内实验研究[J]. 肿瘤防治研究, 2005, 32(02): 67-69. DOI: 10.3971/j.issn.1000-8578.2466
YANG Wu-shuang, LIU Jin-feng, YANG De-lin, YUE Wu. The Effect of a Selective Cyclooxygenase-2 Inhibitor Celecoxib on C6 Gl ioma in Vivo[J]. Cancer Research on Prevention and Treatment, 2005, 32(02): 67-69. DOI: 10.3971/j.issn.1000-8578.2466
Citation: YANG Wu-shuang, LIU Jin-feng, YANG De-lin, YUE Wu. The Effect of a Selective Cyclooxygenase-2 Inhibitor Celecoxib on C6 Gl ioma in Vivo[J]. Cancer Research on Prevention and Treatment, 2005, 32(02): 67-69. DOI: 10.3971/j.issn.1000-8578.2466

COX-2 选择性抑制剂Celecoxib 治疗胶质瘤的体内实验研究

详细信息
    通讯作者:

    杨武双

  • 中图分类号: R730. 264

The Effect of a Selective Cyclooxygenase-2 Inhibitor Celecoxib on C6 Gl ioma in Vivo

More Information
    Corresponding author:

    YANG Wu-shuang

  • 摘要: 目的 探讨选择性环氧化酶-2抑制剂Celecoxib(塞来昔布)对C6胶质瘤生长抑制的体内实验研究。方法 将成瘤小鼠分为对照组和治疗组,应用肿瘤HE染色法、肿瘤生长曲线、前列腺素E2(PGB)检测及电镜检查方法观察Celecoxib对小鼠移植瘤的作用。结果 HE染色和电镜可见治疗组血管破坏、细胞坏死和凋亡,PGE2检测及肿瘤生长曲线分析有统计学意义,P<0.05。结论 Celecoxib能够抑制COX-2活性。降低PGB合成,Celecoxib对C6胶质瘤生长具有抑制作用,对胶质瘤的治疗有重要意义。

     

    Abstract: Abstract :Objective  To investigate celecoxib's function of suppressing the growth of C6 glioma and inducing apoptosis in vivo. Methods  C6 glioma mice were divided into cont rol and celecoxib group, used HE staining、curve of tumor volume 、PGE2 and elect ron microscope to observe the effect of celecoxib on C6 glioma. Results HE staining and elect ron microscopy showed vascular injury, cell necrosis and apoptosis in celecoxib group, PGE2 and tumor volume between two groups through t2test had a statistical mening, P< 0. 05. Conclusion  Celecoxib can inhibit COX-2, decrease synthesize of PGE2, there was a inhibition of proliferation on C6 glioma by celecoxib.

     

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出版历程
  • 收稿日期:  2003-12-28
  • 修回日期:  2004-03-24
  • 刊出日期:  2005-02-04

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