乳腺癌中pS2、HSP27、Cath-D的表达及临床意义

Expression and Clinical Significance of pS2、HSP27、Cath-D in Breast Cancer

摘要: 目的　探讨乳腺癌雌激素调节基因 pS2、HSP2 7、Cath D表达的临床意义。方法　采用免疫组化S -P法检测 50例原发性乳腺浸润性导管癌中ER、pS2、HSP2 7、Cath -D的表达。结果　pS2的表达与ER呈正相关性 (P <0 .0 1) ;与组织学分级呈负相关性 (P <0 .0 5)。HSP2 7表达与淋巴结转移、组织学分级及ER状态无相关性。有淋巴结转移的乳腺癌, 间质Cath -D高表达率显著高于无淋巴结转移者 (P<0 .0 1)。结论　pS2表达与ER有关, pS2确能反映乳腺癌雌激素调节系统的完整性。间质Cath D表达与淋巴结转移有关, 可作为判断乳腺癌预后的指标

Abstract: Objective To study the clinical significance of Estrogen regulated gene pS2?HSP27 and Cath D in breast carcinoma. Methods By S P immunohistochemical staining,the expressions of ER? pS2?HSP27 and Cath D were investigated in paraffin embedded tissue from 50 patients with primary invasive ductal carcinoma of the breast. Results There was positive correlation between pS2 expression and ER expression( P < 0.01 ). There was negative correlation between pS2 expression and histological grade ( P <...