Abstract: Objective To study the expression of PTTG and c-myc in esophageal squamous carcinoma and correlation with clinic pathological features. Methods Immunohistochemical SP method was used to detect the expression of PTTG and c-myc proteins in 48 esophageal carcinoma tissues and para-cancerous tissues. Results The positive rates of PTTG and c-myc in esophageal carcinoma tissues were 72.9%(35/48)and 67.7%(32/48)respectively, which were significantly higher than that in para-cancerous tissues (10.4%and 14.6%, P<0.05).The positive expression of PTTG and c-myc was correlated with lymph node metastasis and TNM staging. There was no relationship with age, gender，tumor size and histological grades,respectively.At the same time,the expression of PTTG and c-myc was positive correlation (P<0.05). Conclusion PTTG and c-myc are over-expressed in esophageal carcinoma.They may play a cooperative role in development, in invision and metastasis of esophageal carcinoma.