Abstract: Objective 　This study was designed to investigate the correlation between CDH1 3′2 U TR + 54 locus C/ T SNP and susceptibility to lung cancer in Northern Chinese population. Methods 　3′2 U TR + 54 locus C/ T SNP was genotyped by polymerase chain reaction rest riction f ragment length polymorphism (PCR2RFL P) analysis in 194 lung cancer patient s and 223 healthy cont rols. Results 　The number of the smokers in lung cancer patient s was significantly higher than that in healthy cont rols. Smoking may in2 crease the risk of developing lung cancer odds ratio (OR) = 3. 03, 95 %( CI) = 2. 03～4. 54 . The C al2 lelotype f requence of CDH1 in lung cancer patient s was 85. 6 %, which was significantly higher than that in healthy cont rols (χ2 = 10. 09, P = 0. 00) . The T/ T, T/ C and C/ C genotype f requencies of lung cancer patient s and healthy cont rols were 1. 0 %, 26. 8 %, 72. 2 % and 4. 0 %, 38. 1 %, 57. 8 %, respectively. Compared with individuals with T/ T or T/ C genotype, individuals with C/ C genotype had significantly higher risk in developing lung cancer (OR = 1. 89, 95 %CI = 1. 25～2. 85) . Conclusion 　The C/ C genotype of CDH1 3′2 U TR + 54 locus might be a potential risk for lung cancer development in Northern Chinese population.