Abstract: Objective 　To study the correlation of EGFR、c2erbB22 and VEGF expression in colorectal car2 cinoma and their significances to clinicopathological character. Methods 　We studied the expression level of EGFR、c2erbB22 and VEGF in 61 cases of colorectal carcinoma by Envision method and analysed the correlation of the expression level and colorectal carcinoma clinicopathological character by Multiple linear regression. Results 　The respectively high expression rate of EGFR、c2erbB22 and VEGF was 49. 2 %, 73. 8 % and 70. 5 %. Multiple linear regression shows that the high expression of EGFR、c2erbB22 and VEGF were related with the tumor size 、lymph nodes metastasis、liver metastasis and Dukes' stages, but not correlated with gender and age. Conclusion 　The result s suggest that the high expression of EGFR、c2erbB22 and VEGF is an useful tool for providing information about the malignant degree, prognosis, and may be as a gaiding in postoperative chemotherapy selection for patient s with colorectal carcinoma.