大肠癌中β-catenin表达及与COX-2、VEGF表达的关系

汪洋; 林从尧; 周夏

doi:10.3971/j.issn.1000-8578.1564

大肠癌中β-catenin表达及与COX-2、VEGF表达的关系

武汉大学中南医院肿瘤科

详细信息

通讯作者:
汪洋

中图分类号: R735. 3 4
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出版历程
- 收稿日期: 2005-05-03
- 修回日期: 2005-07-12
- 刊出日期: 2006-01-04

Expression of β-catenin in Human Colorectal Carcinoma and Its Relationship to Expression of COX-2 with VEGF

Department of Oncology; Zhongnan Hospital; Wuhan University; Wuhan 430071; China

More Information

Corresponding author:
WANG Yang

摘要

摘要: 目的探讨大肠癌组织中β-catenin的异常表达的意义及与COX-2、VEGF表达的关系。方法应用免疫组化SP法检测78例大肠癌组织和15例癌旁正常粘膜组织中β-catenin、COX-2、VEGF的表达。结果β-catenin在15例正常组织均呈正常表达,而COX-2和VEGF均呈阴性。大肠癌中β-catenin异常表达率为75.6%,COX-2和VEGF阳性表达率分别为65.4%、70.5%。β-catenin异常表达与大肠癌的分化程度、转移和Dukes′分期显著相关(P<0.05)。COX-2、VEGF表达水平与大肠癌转移、Duke′s分期有统计相关性(P<0.05)。β-catenin异常表达与COX-2和VEGF的表达在大肠癌中均有显著的正相关性(P<0.05,r=0.278、0.419)。结论β-catenin在胞浆或胞核内的异常聚集以及COX-2和VEGF的过度表达共同参与大肠癌的进展。
- β-catenin /
- COX-2 /
- VEGF /
- 大肠癌 /
- 免疫组织化学
Abstract: Objective To investigate the replationship between the abnormal expression of β-catenin and the high expression of COX-2 and VEGF and its significance. Methods The expression of β-catenin and COX-2 and VEGF were detected in 78 cases of colorectal carcinoma and 15 cases of normal colorectal mucous tissues around the foci by immunohistochemical method. Results β-catenin was expressed normally in 15 cases of the normal colorectal mucous tissue,while COX-2 and VEGF were negative. The expression rate of COX-2, VEG...
- β-catenin /
- COX-2 /
- VEGF /
- Colorectal carcinoma /
- Immunohistochemistry