Abstract: Objective 　To investigate the expression of anti-apoptotic gene bag-1 and bcl-2 and their clinical significances in colorectal carcinoma . Methods 　The expressions of bag-1 and bcl-2 in 20 normal colorectal mucosa 、35 colorectal adenoma and 82 colorectal carcinoma were examined with S-P immunohistochemical staining. Results 　The positive rates of bag-1 in normal colorectal mucosa 、colorectal adenoma and carcinoma were 10%、60%、81% respectively. The positive rates of bcl-2 in colorectal mucosa 、adenoma and carcinoma were 25%、80%、65% respectively. The positive rates of bag-1 and bcl-2 expression in colorectal adenoma and carcinoma were significantly higher than that in normal colorectal mucosa ( P<0. 05) . A significant correlation was found between bag21 expression in colorectal carcinoma and their clinicopathological featers such as differentiation degree 、Duke' s stage and lymph node metastasis ( P<0. 05) . The expressions of bcl22 were not related to the age and sex of patient s、differentiation degree、Duke's stage and lymph node metastasis ( P>0. 05) . Conclusion 　bag-1 and bcl-2 overexpression might play an important role in the occurence of colorectal carcinoma. The expression levels of bag-1 protein is related to the malignant degree of colorectal carcinoma and may be a new biomarker in predicting the potent invasion and the metastasis of colorectal carcinoma.