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斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌

魏素菊, 史 健, 刘义冰, 翟宝娥

魏素菊, 史 健, 刘义冰, 翟宝娥. 斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌[J]. 肿瘤防治研究, 2005, 32(12): 787-789. DOI: 10.3971/j.issn.1000-8578.1540
引用本文: 魏素菊, 史 健, 刘义冰, 翟宝娥. 斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌[J]. 肿瘤防治研究, 2005, 32(12): 787-789. DOI: 10.3971/j.issn.1000-8578.1540
WEI Su-ju, SHI Jian, LIU Yi-bing, ZHAI Bao-e. Clinical Study of Aiyishu Associated NP Regimen of Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(12): 787-789. DOI: 10.3971/j.issn.1000-8578.1540
Citation: WEI Su-ju, SHI Jian, LIU Yi-bing, ZHAI Bao-e. Clinical Study of Aiyishu Associated NP Regimen of Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(12): 787-789. DOI: 10.3971/j.issn.1000-8578.1540

斑蟊酸钠维生素B6注射液联合NP方案治疗非小细胞肺癌

详细信息
    通讯作者:

    魏素菊

  • 中图分类号: R730. 53 ; R734. 2

Clinical Study of Aiyishu Associated NP Regimen of Non-small Cell Lung Cancer

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    Corresponding author:

    WEI Su-ju

  • 摘要: 目的 探讨以斑蟊酸钠维生素B6注射液(艾易舒)联合NP方案对非小细胞肺癌治疗的疗效。方法 将72例非小细胞肺癌患者分为实验组和对照组。分别观察艾易舒+NP(实验组)与单独应用NP方案(对照组)的近期疗效并分析治疗前后肿瘤药敏实验的结果。结果 实验组、对照组的近期疗效分别为60.0%和36.1%(P〈0.05);临床受益率分别为90.0%和63.9%(P〈0.01)。治疗前实验组、对照组肿瘤药敏实验分别为80.0%和80.6%(P〉0.05);治疗后两组的总敏感率分别为87.5%和63.9%(P%0.05)。结论 在治疗非小细胞肺癌的有效率和临床受益率方面,艾易舒联合NP方案明显优于NP方案;艾易舒能够升高患者白细胞,与化疗合用可减少骨髓抑制的发生;艾易舒联合NP方案明显提高了抗肿瘤药物的敏威性,有重明显的抑瘤作用.

     

    Abstract: Objective  To observe the response of Aiyishu associated NP regimen in the t reatment for nonsmall cell lung cancer (NSCLC) . Methods  Seventy-six patients with NSCLC were randomly devided into treatment group (Aiyishu associated NP regimen) and control group (NP regimen ) to study the clinical effective rate and results of sensitive drug trial of tumor before and after treatment for both groups. Results  The partial response rate was 60. 0 % in treatment group and 36. 1 % in cont rol group ( P < 0. 05) ; the overall disease control rate was 90. 0 % and 63. 9 % respectively. The effective rate of drug trial is 80. 0 % in t reatment group and 80. 6 % in cont rol group ( P > 0. 05) before t reatment and is 87. 5 % and 63. 9 % respectively af ter t reatment ( P < 0. 05) . Conclusion  The regimen of Aiyishu associated NP is more effective and less toxicity one than NP regimen. It can improve the sensitive drug t rial of tumor and worths to further investigations in a large, multicenter climical study.

     

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出版历程
  • 收稿日期:  2005-08-29
  • 修回日期:  2005-08-25
  • 刊出日期:  2005-12-04

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