Abstract: Objective To detect the association of the expressive levels of hepatocyte growth factor and c-Met with the clinicobiologic behavior in gastric carcinoma and the correlation between these two factors. Methods Immunohistochemistry method was used to detect the expression of HGF and c-Met in gastric cancer and normal tissues near the tumor borderline. Results The expression of HGF had the positive correlation with histologic types, infiltration depth, clinical stage and lymph node metastasis （P＜0.05）. No correlation was found in age or tumor diameter(P＞0.05). The expression of c-Met had the positive correlation with histologic types and lymph node metastasis (P＜0.05). No correlation was found in age, tumor diameter, infiltration depth and clinical stage (P＞0.05). And HGF had a positive correlation with c-Met in gastric cancer（r=0.342，P＜0.05）. Conclusion HGF and c-Met may improve the growth and metastasis of gastric carcinoma. They could be prognostic markers for gastric carcinoma.