胃泌素和Ki-67在胃癌及其癌前病变中的表达

石国庆; 赵 逵; 王 红; 刘模荣

doi:10.3971/j.issn.1000-8578.2009.09.011

胃泌素和Ki-67在胃癌及其癌前病变中的表达

Expression of Gastrin and Ki-67 in Gastric Cancer and Precancerous Pesions

摘要

摘要: 目的研究不同胃黏膜病变组织中胃泌素和Ki-67的表达，探讨胃泌素在胃癌发生中的作用。方法 96例不同胃黏膜病变组织来自胃镜活检标本。采用免疫组织化学染色技术检测胃泌素和Ki-67表达。结果胃泌素在浅表性胃炎（CSG）、萎缩性胃炎（CAG）、肠化生（IM）、异型增生（Dy）和胃癌（GC）中表达的阳性率分别为58.8 %、30.0%、57.9 %、68.2%和77.8%，CAG组与GC组比较，差异有统计学意义(P<0.05)；从CSG→GC，Ki-67增殖指数（PI）呈逐渐递增趋势，且从CAG→GC，胃泌素的表达与PI呈正相关（P<0.05）。结论胃泌素在萎缩性胃炎中呈低表达，在胃黏膜肠化生、异型增生及胃癌中，表达异常增高；胃泌素与胃癌的发生有关。

Abstract: Objective To investigate the expression of gastrin and Ki-67 in different gastric mucosal lesions and to assess the role of gastrin in the gastric carcinogenesis. Methods 96 samples with different gastric mucosal lesions were obtained by gastroscope. The expression of gastrin and Ki-67 was examined with immunohistochemical staining technique. Results Positive rates of gastrin expression in chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), intestinal metaplasia(IM), dysplasia (Dy) and gastric cancer(GC) were 58.8 %,30.0%,57.9 %, 68.2% and 77.8%, respectively. There were significant differences between GC and CAG. Ki-67 proliferation index (PI) also showed an increase tendency from CSG, CAG, IM, Dy to GC. From CAG to GC, the expression of gastrin was positively correlated with PI (P<0.05). Conclusion Gastrin expression decreased in CAG. From CAG to GC, gastrin expression increased gradually. Gastrin may take part in gastric precancerous.

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