CD44v6、EGFR及nm23-H1基因蛋白在食管鳞癌组织中的表达及意义
The protein expressions and significances of CD44V6、EGFR and nm23-H1 genes in esophageal squamous cell carcinoma
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摘要: 目的 探讨食管鳞癌中CD4 4v6、EGFR及nm2 3 H1蛋白表达的意义。方法 应用免疫组化S P法检测 5 0例食管鳞癌中CD4 4v6、EGFR及nm2 3 H1蛋白表达。结果 CD4 4v6、EGFR、nm2 3 H1蛋白表达总阳性率分别 6 4 %、70 %、5 0 % ;显示CD4 4v6及EGFR阳性表达率与食管鳞癌分化程度、浸润深度及淋巴结转移率呈正相关 (P <0 .0 5及P <0 .0 1), 与患者预后呈负相关 (P <0 .0 0 5 ) ;而nm2 3 H1蛋白表达则与以上两者表达状况相反。结论 同时检测食管鳞癌中CD4 4v6、EGFR及nm2 3 H1基因蛋白表达水平, 对判断食管鳞癌恶性程度、浸润转移潜能及评估患者预后有一定参考价值。Abstract: Objective To explore the protein expressions and their significances of CD44v6、EGFR and nm23-H1 gene in esophageal squamous cell carcinoma. Methods The protein expressions of CD44v6、EGFR and nm23-H1 were detected in 50 cases of esophageal squamous cell carcinoma with s-p immunohistochemical method. Results The positive rates of CD44v6、EGFR and nm23-H1 in 50 cases of esophageal squamous cell carcinoma were 64%、70% and 50%,respectively. There was a positive relationship between positive expressions of CD44...
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