Abstract: Objective To explore the expression of nm23 gene and ras gene and the correlation with lymph node metastasis. Methods By using SP immunohistochemical methods,the nm23 H 1 and rasp21 expression of 76 breast tissues were detected,and the 5 year survival rate were followed up. Results nm23 H 1 gene expression were negative correlation with histologic tumor grade and lymph node metastasis ( P<0.005,P<0.05 ), and its expression was negative correlation with rasp21 expression in breast cancers,the pati...