鼻咽癌HK-Ⅱ和VEGF表达与PET/CT 显像18F-FDG摄取的关系

石卫民; 范义湘; 宋维舒; 黎静; 尹吉林

doi:10.3971/j.issn.1000-8578.2011.01.013

鼻咽癌HK-Ⅱ和VEGF表达与PET/CT 显像18F-FDG摄取的关系

Relationship between Overexpression of Hexokinase-Ⅱ and Vascular Endothelial Growth Factor in Nasophygeal Carcinoma and Fluorodeoxyglucose Uptake of PET/CT

摘要

摘要: 目的探讨鼻咽癌的18F-FDG摄取与肿瘤组织己糖激酶-Ⅱ(hexokinase-Ⅱ, HK-Ⅱ)及血管内皮细胞生长因子（VEGF）表达的关系。方法对2005年3月至2006年8月收治的40例鼻咽癌患者进行正电子发射体层显像（PET）检查，测定肿瘤最大和标准摄取值（SUVmax和SUVmean）；应用标准链霉菌抗生物素蛋白-过氧化物酶亲和（SP）免疫组织化学法检测40例患者肿瘤组织己糖激酶-Ⅱ 和血管内皮细胞生长因子（VEGF）的表达。结果 40例鼻咽癌组织的SUVmax与 SUVmean分别为（9.45±1.87）和（6.04±1.09）；40例鼻咽癌组织HK-Ⅱ阳性细胞率为68.33%，VEGF染色阳性细胞率为60.8%；鼻咽癌组织FDG摄取（SUVmax）和HK-Ⅱ表达的细胞阳性率呈显著相关（r=0.493,P＝0.001），鼻咽癌组织FDG摄取（SUVmax）和VEGF表达的细胞阳性率相关（r=0.460,P＝0.03）。结论鼻咽癌组织FDG摄取与HK-Ⅱ和VEGF过度表达相关。

Abstract: Abstract:Objective To assess the relationships among the overexpression of hexokinase-Ⅱ（HK-Ⅱ) and vascular endothelial growth factor（VEGF）and fluorine-18 fluorodeoxyglucose (FDG) uptake of tumors in patients with nasophageal carcinoma. Methods From March 2005 to August 2006,40 patients with nasophageal carcinoma were imaged with FDG positron emission tomography(PET).Their maximum and mean standard uptake value (SUVmax and SUVmean)were measured.The expression of HK-Ⅱ and vascular endothelial growth factor of 40 cases was studied in paraffin sections by SP immunohistochemistry. Results The FDG uptake of tumors in 40 patients with nasophageal carcinoma were (9.45±1.87)（SUVmax） and (6.04±1.09)(SUVmean) respectively.The tumor tissues in 40 patients were tested to be HK-Ⅱ positive and VEGF positive.The ratio of HK-Ⅱ positive cells were 68.33% and VEGF positived cells were 60.80%,respectively in the tumor tissues.There were correlations between HK-Ⅱ expression and tumors'FDG uptake（r=0.493,P＝0.001）and between VEGF expression and tumors'FDG uptake（r=0.460,P＝0.03）. Conclusion Overexpression of HK-Ⅱ and VEGF correlates with FDG uptake in patients with nasophageal carcinoma.

HTML全文

参考文献(0)

施引文献

资源附件(0)