Abstract: Abstract:Objective To investigate the effects of Ginsenoside CK on the cell proliferation、cell cycle and endogenous VEGF of gastric cancer SGC-7901 cell line. Methods SGC-7901 cell line in cultural medium in vitro were given 50，25，12.5，6.25，3.125，1.5625 μg/ml Ginsenosde CK. The inhibitory rate of cell line was measured by MTT assay; cell apoptotic rate and cell phase were detected by flow Cytometry (FCM); the VEGF contents were detected by ELISA assay. Results It was found that Ginsenoside CK had significant inhibitory effect on the proliferation of SGC-7901 cell line,and this effect was dose-and-time-dependent; FCM assay indicated that apoptosis peak appeared evidently after the cells being interfered with Ginsenoside CK and most of cells were arrested in G0/G1 phase; The levels of VEGF in Ginsenoside CK groups were lower than that in the control group (P<0.05). The level of VEGF in the groups of high concentration Ginsenoside CK were lower than that in the group of low concentration(P<0.05), and the VEGF contents decrease with action time prolonging. Conclusion Ginsenoside CK dramatically inhibits proliferation of SGC-7901 cell line by inducing cell apoptosis and secretion of endogenous VEGF. Ginsenoside CK may become a potential drug in the prevention and treatment of gastric cancer.