Abstract: Objective 　To observe the curative effect with t ropiset ron, droperidol and PCA to prevent nausea and vomiting caused by IPC with cisplatin. Methods 　44 cases of I～II grade ASA were used cisplatin to IPC during operation, and were divided into group A : t ropiset ron 5mg + droperidol 2. 5mg + fentyli 1. 0mg and group B (cont rol group) : droperidol 5mg + fentyli 1. 0mg randomly. Cisplatin was injected into abdominal cavity before suture. af ter t ropiset ron 5mg and saline solution were iv, PCA pump were linked to the patient s in these two groups. Results 　The excellent rate of group A is 95. 5 % in 10 hours after operation, compare to the 68. 2 % and 59. 1 % of group B, there was a significant difference ( P <0. 01 、0. 05respectively) . During 10～36 hours af ter operation, the excellent rate of group A was declined to 90. 9 %, compare to the 63. 6 % of group B, there was also a significant difference ( P < 0. 05) . Conclusion 　In the appropriate concent ration, combined hydrochloride tropiset ron, droperidol with PCA can preferable prevent nauseaing and vomiting during operation caused by IPC with cisplatin.