Src家族酪氨酸激酶Fyn在肺鳞状细胞癌组织中的表达及意义

Expression significance of Src Family Throsine Kinase Fyn in Pulmonary Squamous Cell Carcinoma

摘要: 目的：探讨肺鳞状细胞癌组织中Fyn的表达水平及其意义。方法:采用免疫组织化学法和免疫印迹法分析肺鳞状细胞癌组织及正常肺组织Fyn蛋白表达水平的变化。结果:免疫组织化学染色显示肺鳞状细胞癌组织中Fyn蛋白表达水平（12.54±2.45）高于癌旁正常肺组织中染色指数(4.34±1.27)，差异有统计学意义（P＜0.01）。免疫印迹结果亦显示肺鳞癌组织中Fyn蛋白表达强于癌旁正常肺组织。结论:Fyn蛋白在肺鳞状细胞癌组织中过度表达，提示Fyn基因在肺鳞状细胞癌的发生发展过程中起重要作用。

Abstract: Objective：To determine whether Fyn expression was altered in pulmonary squamous cell carcinoma (SCC) compared with pericancerous normal lung tissue (NORMAL). Methods ：We examined Fyn expression in pulmonary SCC and compared it to the normal lung tissue by immunohistochemical staining and immunoblotting. Results ：By immunohistochemical staining Fyn protein expression levels are increased in pulmonary SCC (12.54±2.45) compared to the NORMAL(4.34±1.27), P＜0.01.Meanwhile, we got the similar Results： by immunoblot analysis. Conclusion ：Fyn may act as an important molecule in the pulmonary SCC regulation.