Abstract: Objective：To discuss the relationship between AKT, p-AKT, AKT2, VEGF-C expression and lymphatic metastasis of breast invasive ductal carcinoma (IDC) and to research the relevance between AKT and VEGF-C, p-AKT and VEGF-C, AKT2 and VEGF-C in IDC. Methods：RT-PCR was used to detect the expressions of AKT2 and VEGF-C mRNA on 17 fresh breast cancer tissues.Immunohistochemical (IHC) method (SP) was used to examine the expressions of AKT, p-AKT, AKT2 and VEGF-C protein in paraffin-embedded specimens of 74 breast invasive ductal carcinomas.Western-blot was used to detect the expressions of AKT, p-AKT, AKT2 and VEGF-C protein on 17 fresh breast cancer tissues. Results ：The expression of AKT2 mRNA in IDC with lymphatic metastasis was higher than that in IDC without lymphatic metastasis （P<0.05）.And there was no significant difference on the expression of VEGF-C mRNA（P>0.05）.The difference between the expressions of AKT2 and VEGF-C protein in the two groups were statistically significant (P<0.05).There was no significant differences between the expression of AKT and p-AKT protein in the two groups (P>0.05).The expressions of p-AKT, AKT2 and VEGF-C protein in metastasis group were higher than those in non-metastasis group.There was no significant difference on the expression of AKT protein between two groups.There were significant positive correlations between expression of AKT and VEGF-C, p-AKT and VEGF-C in breast cancer （r＝0.283，P＝0.015；r＝0.328，P＝0.004）.There was no significant correlations between expression of AKT2 and VEGF-C in IDC (r＝0.072, P＝ 0.543). Conclusion ：The expressions of AKT2 and VEGF-C were closely related to lymphatic metastasis of IDC.AKT2 and VEGF-C can be used as predictors of lymphatic metastasis.