宫颈癌中survivin的表达及临床意义

Expression of survivin in Cervical Carcinomas and Its Clinical Significance

摘要: 目的　探讨调亡抑制基因survivin在宫颈癌组织中的表达及临床意义。方法　应用免疫组化方法检测survivin和cyclinB1蛋白在 5 6例宫颈癌和 18例正常宫颈组织中的表达, 并将结果进行了相关分析。结果　 6 9.6 % (39/5 6 )宫颈癌中表达survivin基因, 而在正常宫颈组织为 16 .7% (3/18) (P <0 .0 1) ;survivin基因表达与宫颈癌组织细胞类型及分化程度无明显相关关系, 但与年龄、临床分期和淋巴结转移有关。宫颈癌组织中cyclinB1表达与survivin表达显著相关。结论　cyclinB1和survivin在细胞周期中有协同作用, 它们的过度表达可能是宫颈癌癌细胞G2 /M过渡的促进因素。survivin基因有可能成为宫颈癌基因治疗的靶点。

Abstract: Objective To study the expression of a inhibitor gene of apoptosis,survivin,in cervical carcinoma and its clinical significance. Methods Using immunohistochemical method,we examined the expression of survivin and cyclinB1 in 18 normal cervical tissues and 56 cervical carcinomas and analyzed the relationship of the results. Results Expression of survivin gene was detected in a significantly greater proportion of cervical carcinoma( 69.6%,39/56) than adjacent normal cervical tissues( 16.7%,3/18) (P< 0.0...